During their appearance on Jimmy Kimmel Live!, Dr. Dre, Snoop Dogg, and 50 Cent participated in a comedic skit titled “Dre’s Anatomy,” a playful parody of the popular medical drama Grey’s Anatomy. The skit revolves around Kimmel’s character being rushed into an operating room, where Dre, playing the role of a surgeon, and his companions hilariously attempt to locate Kimmel’s missing penis. Despite Kimmel’s protests that he does indeed possess the organ, Dre and Snoop humorously dispute his claim, leading to the involvement of 50 Cent as a specialist.
As the trio comically struggles to identify Kimmel’s genitalia, they eventually succeed with the help of a telescope wielded by 50 Cent. However, their discovery is met with amusement and mild shock as they liken Kimmel’s penis to chewed bubblegum, with 50 Cent comparing its appearance to Juicy Fruit. Despite Kimmel’s initial intention of undergoing a colonoscopy, the skit ends with him being anesthetized by Snoop’s smoke, set to the instrumental of “Still D.R.E.,” as the procedure to reattach his penis begins.
In addition to “Dre’s Anatomy,” Jimmy Kimmel Live! also teased a faux preview of a fictional medical drama called EM, starring Eminem, reminiscent of the iconic TV series ER. The skit showcased the comedic talents of the rap legends in a light-hearted and entertaining manner, providing a memorable moment for viewers of the late-night show.